Insuline patch

Schematic mechanism of the glucose-sensitive smart insulin patch. The smart patch monitors blood sugar or glucose. It contains insulin doses in very few micronodels, which are less than 1 millimeter in length, when the blood glucose levels reach a certain threshold, the drug is administered quickly.

When blood sugar returns to normal, your insulin supply also slows down. The researchers said the advantage is that it can help prevent insulin overdose. Which can lead to hypoglycemia, seizures, coma, or even death.

It has always been a dream to achieve insulin delivery in a smart and convenient way, study co-author Dr. This smart insulin patch, if proven safe and effective in human trials, will revolutionize the diabetes patient experience. Insulin is a hormone that occurs naturally in the pancreas. It helps the body regulate glucose, which comes from eating food and provides energy to the body. Insulin is the molecular key that helps transfer glucose from cells in the blood for energy and storage.

In any case, a regular dose of insulin is prescribed to control the disease, which affects more than million people worldwide. Not much has changed in decades of treatment for the disease in most parts of the world. Diabetes patients will draw their blood using a device that measures glucose levels. They will then self-administer a required dose of insulin. Insulin can be injected with a needle and syringe, administered by a pen-like device, or an insulin pump, which is a portable device the size of a cell phone connected to the body through a tube with a needle in the extreme.

The micrononels used in the patch are made with an insulin encapsulated glucose sensor polymer. Once applied to the skin, the microneedles penetrate under the skin and can feel the blood sugar levels. If glucose levels rise, the polymer triggers to release insulin.

The microneedle is smaller than a common needle used to draw blood. It does not reach depth either, making it less painful than a puncture. It penetrates approximately half a millimeter under the skin, which is enough to administer insulin to the body. In experiments, a quarter-size patch successfully controlled glucose levels in pigs with type I diabetes for approximately 20 hours. The pigs weighed on average about 55 pounds.

USA, which helps companies during the regulatory process. The researchers are requesting FDA approval for human clinical trials. Which they believe could begin in a few years.

The team imagined that the smart microneedle patches could be adapted with different medications to control other medical conditions.

This coin-shaped smart insulin patch can control glucose to control diabetes. Researchers from three universities have developed a smart insulin delivery patch that has the ability to monitor and control glucose levels in people with diabetes. It is the size of a coin and can be easily manufactured for single use.

The research on the smart insulin patch was done in mice and pigs and in it was successful in mouse testing at UNC. The team is now seeking FDA approval for human clinical trials. Our main goal is to improve the health and improve the standard of living of people with diabetes, Professor Jane Gu of Bioengineering and UCLA said in a press release. It mimics the regulatory function of the pancreas but in a user-friendly way.

The adhesive patch monitors blood sugar and pre-filled insulin doses in small microns on the patch to deliver the medication quickly when glucose levels reach a certain level. Once glucose levels return to the normal range, insulin delivery slows down. It has always been a dream to administer insulin intelligently and conveniently, said study co-author John Buse. This smart insulin patch, if proven safe and effective in human trials, will revolutionize the patient experience in diabetes care.

The microneedles in the patch are made of a glucose-sensing polymer that bonds with insulin. Once the patch is on the skin, the microneedles penetrate under the skin and begin to feel glucose levels.

If glucose changes, the polymers in the patch release insulin through microneedles. Which are less than 1mm in length. Note that the EZ Fill should not be used for more than 30 fills. It, too, will need to be disposed of according to local regulations, with the last insulin vial used attached.

You'll get a new EZ Fill every 30 days with your prescription. Every time you fill a new patch, leave the insulin vial attached to the EZ Fill and place it in a clean, dry area of the refrigerator. Find a dry place to store your unused V-Go patches that's out of reach of children and pets. There are two potential adverse reactions from using V-Go. As with any supplemental insulin, there is a risk of hypoglycemia low blood sugar or hyperglycemia high blood sugar associated with using V-Go.

As such, the manufacturer notes the product is not appropriate for patients who must make regular adjustments or modifications to their basal rate during a hour period, or whose insulin at mealtimes requires adjustments of less than 2-unit increments.

This happens rarely, but it's advisable to monitor your blood sugar at least three times a day or as often as your healthcare provider tells you to , as well as before you drive or operate heavy machinery. A drop in glucose levels can interfere with alertness. Take immediate action to raise your levels by taking glucose tablets, eating candy, drinking juice, or otherwise doing as your healthcare provider or healthcare professional has advised you to.

Hyperglycemia can progress to a potentially fatal condition called diabetic ketoacidosis DKA , in which the blood becomes acidic and damage to cells can occur. Again, this is very unlikely to happen, but it's important to stay well hydrated and to know the signs of hyperglycemia so you can call your healthcare provider if you think you may being developing it.

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Effect of V-go versus multiple daily injections on glycemic control, insulin use, and diabetes medication costs among individuals with type 2 diabetes mellitus. J Manag Care Spec Pharm. Clinical benefits over time associated with use of V-go wearable insulin delivery device in adult patients with diabetes: A retrospective analysis. Adv Ther. V-Go: Wearable Insulin Delivery. Actively scan device characteristics for identification.

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Table of Contents View All. Table of Contents. Who Can Use V-Go. Using V-Go. Side Effects. Insulin Options To use V-Go you will need two prescriptions from your healthcare provider: V-Go itself and a separate insulin prescription. Safe Disposal Like all needles used to inject medication, V-Go should be disposed of according to local requirements. Was this page helpful? Thanks for your feedback! Sign Up. What are your concerns? Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles.

Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy. Related Articles. How to Give an Insulin Injection.